Summary of IVF#1

I feel the need to "summarize" everything that I've been through including the protocol and meds I took, just so I will have this information for myself to reflect on. Perhaps other people may find it interest as well. I guess this is also my way of dealing, closure if you will.


IVF#1 (Nov 2011 - Jan 2012)
Miscarried at 5/6 weeks

Goodbye my little baby~ I wish we could still be together. I wish I could have heard your heart beat. But God had other plans for you. You will be missed. 

Protocol: Antagonist (Patch priming)
Meds:
   Pre-Stim:
     - Estrogen patch: No problem sticking to skin, no side effects felt
     - Orgalutran: Small needle, easy to inject, no burning once I learned how to inject properly
   Stim:
     - 400iu Puregon: Injection by puregon pen, easy to prepare, not too much burning with ice before shot
     - 75iu Repronex: Mixing it was a bit of a hassle, very easy once I got used to it, burns a little after injecting
    # Days of Stimulation: 11 Follicle Count/Size Before Trigger: 3-4 at >17mm, Many smaller ones around 15mm Eggs Retrieved: 10 Mature Eggs: 5 (4 usable, 1 abnormal) Fertilized: 3 (But 2 stopped growing before day 3) Transfered: 1 Day 3 embryo, 8 cell excellent grade Lining: 12mm on day of transfer  Acupuncture: Day of transfer only - once before transfer, and once after
Betas  #1 - 13dp3dt: 11  #2 - 19dp3dt: 324 (Started heavy bleeding)  #3 - 20dp3dt: 157 (Continued bleeding)  #4 - 24dp3dt: 27 (Continued light bleeding)  #5 - 30dp3dt: Not sure yet but probably back to zero

I know I started my first cycle pretty optimistic. It's probably the way all first timers feel. However, the reality is that this is not going to work the first time for everybody. The hardest part about my first cycle was that it ended in miscarriage. Honestly, I'm still coping. This cycle really brought me down to earth about my expectations and it was a hard kick in the ass reality check. The next round will hopefully be easier now I know what to expect. It won't be less stressful but I hope to cycle again soon and I will not give up! "It will be ok in the end! If it's not ok, it's not the end!" - Oprah

What else can I say about my first cycle? Well, Beans is sure happy that he's going to stay an only child (fur-child) for a while. I know he's smirking behind my back....

The end and heartbreak

Last week, waiting for a my second beta was the longest and hardest week I had to go through. December 28 was the end of our journey and the hardest day in my 27 years of exsistance. Fate was unbelievably cruel to me.

The digital home pregnancy test I took the morning of December 28th told me that I was in fact pregnant, which I knew already but I questioned the viability of my pregnancy with a low first beta of 11. But when the words "2-3 weeks"(since conception) appeared in the window of that HPT, I couldn't find the words to describe how happy I was. It felt like that yes, there was a huge chance that this pregnancy may in fact work out! In 6 days, my Hcg went from 11 to above 200 (if in fact the digital was correct) and that put me right back on track to where I'm suppose to me. Yes, my levels were still low, but it gave me a lot of hope. I ran in the bedroom to tell my husband the wonderful news and I was so happy I could cry. I know it didn't mean anything concrete, my number were not official, but it was a ray of hope from heaven. I was on cloud 9. I could now believe that I was 5 weeks pregnant.

That afternoon, my whole world shattered. It shattered so quickly. After doing some casual grocery shopping. We were on our way home in the car. I was thirsty and decided to take a sip of water. Accidentally choking on the water, I began to violently choke and cough for a couple of minutes. I didn't think anything of it at first but after about 5 minutes, my stomach began to feel strange, and before I knew it, I felt something gushing down. When we got home and out of the car, I stood up and I felt it. I knew it was blood and things didn't look good. As we walked towards the elevator, the bleeding became heavier and it soaked through my pants and dripped as I walked to my apartment. I was so scared.

We took a trip to the ER and of course, I was still bleeding. When the nurse asked me what was the matter, I said "I'm pregnant and I'm bleeding" and that was when it hit me. This was the end. I broke down.

We waited for a few hours, they took blood and examined me. When I looked in the toilet bowl after my trips to the bathroom as I was waiting, it was bright red and looked like a crime scene. My beta that night was 324. What a great number it would have been. The doctor sent me home and referred me to an early pregnancy clinic to do an ultrasound. I was only 5 weeks (and some) along and I guess they didn't bother to do an ultrasound. I went home feeling shattered and shocked that my world had went from wonderful to hell in the blink of an eye.

The bleeding continued the next day on the day of my scheduled beta test at my clinic. I told the nurse what happened and she wasn't optimistic. I'm at risk for ectopic pregnancy. My beta the day after the bleeding incident was only 157. The baby is definitely gone. The nurse still felt that I needed to be checked on again so my next appointment will be Jan 3rd for bloodwork and an ultrasound.

So was this a miscarriage? Could it be an ectopic pregnancy? If they don't see anything on the ultrasound, would "they" label this as a chemical pregnancy since nothing was ever seen on the screen?

I felt so connected to the would-be baby. I felt a new life was growing inside me and I thought I would get to be a mother. I guess I was too optimistic too soon and those positive pregnancy tests certainly didn't help. Is it alright to grieve? Am I crazy for feeling so crushed as I am?

My heart goes out to everyone who had a miscarriage. I understand that the further along the pregnancy, the harder the miscarriage will be. I can not begin to imagine how those that lost their angel after seeing it on the screen must have felt. But I'm also hurting and grieving, I hope that's alright.

I hope that this is over and done with quickly. I hope this doesn't turn out to be ectopic and no further intervention will be needed. But every trip to the bathroom just reminds me that I couldn't keep my would-be baby. What do I do now?

Holding my breath

I caved and went out and bought a ClearBlue Digital with Conception indicator.
My beta at 13dp3dt was 11. Now 6 days later, the CB is telling me that I'm 2-3 weeks pregnant! I'm hoping that this is a good sign and it will continue to rise and I'll have a normal pregnancy!

I guess we can rule out chemical pregnancy now... maybe... I won't know for sure until my beta tomorrow. I'm holding my breath and keeping everything crossed! I will most likely need a 3rd beta.

I read somewhere that to get 2-3 weeks on the CB test, your hcg should be around 200. Although unclear about the accuracy of this piece of information or the test itself, it's giving me a little peace of mind at least for today! The worry never ends!

Still (a little?) pregnant?

Yup... It's not Thursday yet... How time drags on during these in-between days... I hate living my life in increments. All I can think about is my next beta.

The ClearBlue still tells me that I'm pregnant. So at least I still somewhat have hope. The line does look a bit darker than 2 days ago... I'm pulling my hair out thinking, just how high my beta can go from an original reading of 11???

How could the clinic do this to me? 1 whole week in-between betas?? Tell me how to get this off my mind!!! I'm just about ready to join a mental institution!!

Beta Hell

I never thought I'd be where I am today... With all my early HPTs being negative before my Beta at 13dp3dt... I was scared to death to test again before my beta so I just accepted that yes, my first cycle would be a failure...

Then... my first beta at 13dp3dt... was 11...
This was not good news... but not bad news? At least I had a slim chance... Even if it was less than 10% according to some website I found after obsessively goggling success stories with incredibly low betas.

Now, waiting for my second beta during the holidays... I've turned in to a POAS addict!!
I'm afraid my journey through POAS and beta hell has started...

"I wonder if I will still test positive on the evil stick today??"
"Did my second line on the test get darker?"
"How much darker is it?"
"Maybe if I google pictures of HPTs I can figure out my beta number from other people's pictures..."

Yup... I'm in hell!

So I tested 2 days after my first beta of 11 with a First Response Early Result. I had a line, an obvious line. This reassured me that at least my numbers should be more than 11. This was yesterday, Christmas Eve. I was super happy that at least I got to see a second line. This was my first time EVER!

Today, on Christmas, I took a second test with a ClearBlue, and the + line came up in less than 10 seconds, darker than the horizontal line, which also reassured me. But I'm still feeling uneasy.

I have a feeling that this may go on for a while before I know a definitely answer.
My problem is that I'll be out of my progesterone tabs before I go in for my second beta... I may just pop in a regular clinic to ask for a prescription, if that's even possible... sigh...

If this is indeed a chemical pregnancy, I will make my peace with it. I just wish I can find out sooner and move on. What an exhausting journey!

A little pregnant?

Well, it's been ages since I've posted. Since I've last posted, I've had my egg retrieval, transfer, and the dreaded 2 week wait is finally over (or so I thought)...

My egg retrieval was on December 6 at 8:30 in the morning. I had to be at the clinic at 7:30 as they had to prep me for the retrieval. I had a shot of Fentanyl (it's a valium-like drug to relax me) and an IV started in my arm. They also gave me Versed through my IV for the pain. (Like it helped at all!!)

Unfortunately, my retrieval was SUPER painful. The embryologist was late and I guess my meds were wearing off. They gave me a second dose of meds but it was still very painful. I just kept thinking to myself that if I can't take this pain, what about child birth?

Anyway, they retrieved 10 eggs, which I though was good news. However, the nurse called the next morning and only 3 fertilized out of the 10. Then, after another day (or what seemed like a century) of anticipation, only 1 made it to a day 3 transfer. The one good embie was an 8-cell excellent grade embryo so I had a 35% chance of success according to the doctor. I was pretty down as I hoped to put back at least 2 which would have increased my odds to 50%. But life goes on...

Egg Transfer was easy! No pain at all, just a very uncomfortable full bladder. Acupuncture before and after the transfer was also easy (not on the wallet though, it was 283 dollars!) I had the privilege of having a very experienced doctor to do my transfer. I was the last egg transfer that he will ever do, as he is retiring, and the very first egg transfer he did 29 years ago ended up with a positive result. I took that as good luck and my dreaded 2 week wait began.

I won't tell you that the wait was easy because it was the hardest part of the whole process. I caved and used a HPT but it gave me a negative result (even though I stared way pass the 10 minute deadline... I seriously thought staring at the evil stick will change the outcome, I guess I don't have super powers after all...!)

Then today at 13 days past my 3 day transfer... I went in for my big test... the beta!
I was expecting a BIG FAT NEGATIVE and I though was prepared for bad news but... not this!

In the words of the nurse, "It's not good news but, you're a little pregnant."

!?!?

It turns out my beta is 11 at day 13. This is pretty low. It will most likely end in an early miscarriage or what they like to call a chemical pregnancy. I go back for a second beta test a week later to confirm. The nurse said they'd like to see a beta of below 5 to confirm a negative result.

Well, I'm back in beta hell for another week!!! I'm not sure what to think and I'm just a little shocked right now...

Ready Set Jab! First day of Stimulation

The much anticipated Aunt Flo arrived 2 days early~! Whoohoo! I've never been so excited to see it come early. So, I'm starting my stimulation schedule and my retrieval could be just less than 2 weeks away! (Fingers, toes, hairs, eyes, everything crossed!) Number of days that I will need the injections will depend on how I respond. When the ultrasound/bloodwork shows that I am ready, I will take a trigger shot, and 36 hours later is the egg retrieval. The transfer will depend on how many we get and how many was fertilized. Also, we signed up for taking the embies to day 5 if possible. The RE said this will up our chances to 50% for transferring two day 5 embies. Wowzers!

Now let me share some insights on the Puregon pen and the Repronex injection:

This is the Puregon pen process

I just love it love it love it! It's so easy and pain-free. You buy these cartridges and they come in amounts of 300, 600, and 900. The nurse shared with me that each cartridge actually has an extra 100iu of medicine in it! Plus, they are the same price per unit. (Meaning, the 600 is double the prices of the 300 etc...) This is awesome because you actually get more for your money if you buy the 300iu. This just works very well in my case because I am on a 400iu dosage, which means I just use 1 cartridge per injection! Ask your clinic next time if you are using puregon to see if you can save money by working it out. (You may have to jab yourself twice though, if you have to change cartridges in-between...)

I'm just joking... Don't jab your dog... (Ooops I got caught... And there's actually no needle in that, don't panic or call the animal abuse centre)

Here's Puregon's great website with video instructions on using the Puregon pen: Puregon Pen Instructions

Now that you know how to use a Puregon pen, go ahead and have some fun and jab something!!

Here's the Repronex Preparation Process

It's not an instructional video or whatever. But it's just a quick glimpse. I'm actually missing a step where I get 1mL of the diluent from the grey vile and inject it into the purple vile (this is the vile with the medicine). And the in the third picture, I get all the mixed solution back into the syringe. This is easier with practice. It's not as easy as the Puregon but it's not rocket science! 

Some stuff that's helping me survive injection:

- ICE!!!! Ice the area of injection for like 10-20 seconds before you do it. (Also clean the area with your alcohol swab after you do ice it.) It reeeeally reduces the pain and I can't even feel the needle going in. (Injecting the stuff is another issue of course)

- Inject SLOWLY... And try not to be shaky... I couldn't stop shaking and I ended up with a little bruise...

- Drink lots of fluids! That's what the nurse told me anyway!

- Blame everything on the injections. (You can basically get away with anything!)

My Jab Schedule:
Nov 23 - Nov 26 Daily
 1. Puregon 400iu / Repronex 75iu @ 5:30pm
 2. Decadron pill @ bedtime

Nov 27
 First Ultrasound and bloodwork appointment

Now, hopefully the side effects are minimal and I won't be crying every 30 seconds or breaking everything in my house. More updates later!

I NEED my syringe NOW (I swear I'm not a drug addict)

Today is the first injection of my Orgalutran (250ug/0.5mL). Of course I was all excited as I gathered the goodies and arranged them neatly on my desk.

Hmmm I feel like I've forgotten something...

And of course it's the good 'ol ice cube to numb the area. 

Yeah the ice cube is just a precaution. You jab-veterans don't laugh at me now. I am a noobie. 

Injections for Dummies (And those with needle phobia)

Areas of choice for injecting Orgalutran

OK so... injection area this time lower tummy as seen in this wonderful diagram.
   Step 1. Wash hands - check
   Step 2. Cleanse area with alcohol swab - check
   Step 3. Unwrap syringe/Remove needle cap - damn it we can't inject with the cap on? check...

I couldn't help but upload an eerie picture of the syringe...

   Step 4. Carefully push the syringe upwards so that a small droplet appears on the end of the needle - OOPS! you'd think that I was reading directions when I was doing this... Yeah, I forgot to remove the air bubbles....
   Step 5. Pinch the area under the tummy where you will inject. - Mmmm my fat rolls come in handy
   Step 6. Hold syringe so needle is close to skin
   Step 7. Keep holding it for 5 minutes because you are too chicken to jab
   Step 8. Just do it already!
   Step 9. POKE... Ouch, scream, cry, whatever... Inject and hold it there for a few seconds after to make sure all the medicine is in.
   Step 10. Remove syringe and press down with a tissue.

There, I did it! That was easy and didn't take me 10 minutes... sure....

Here's me posing for the camera... (You wonder why it took me 10 minutes..) Come on, it's a memorable experience!! I have to document it!!

Until next time!!! Which is precisely tomorrow November 19, 2011 at 10:00 am, which is when I will say, I NEED MY NEEDLE!

 

Mr Penguin: Oh yeah we totally conquered that one!

Christmas in a paper bag (or two)

Today was my BIG day! I finally picked up  my meds and had the injections 101 talk with my nurse. The whole experience was very pleasant and the nurses and doctors are just so nice!
I was unsure about what and how much stuff I was actually going to be picking up today so I showed up in front of the pharmacy counter, said hello to the friendly pharmacist, and said, "I think I'm suppose to be picking up something here." Of course, she gave me a big smile and dug out 2 big lovely white paper bags filled with pointy goodies. Was it that obvious that I'm a first timer?

How exciting~~~!!

The pharmacist then took out each and every single item, telling me what they are. Then of course, it was time for the bills... Ek! Let's ignore that. (What credit card debt?) She also introduced us to our nurse and she took over from then. 

The nurse took us into a room and gave me my lovely jabbing schedule and walked through each injection with me. Just when I thought I was home free, she asked me to do a mock-jab (is that even a word?) just so I know how it feels and that she can see I am doing it correctly. (Uh oh!!) Pinch, jab, and inject, she says! (Let's hope I don't pass out) In the end, that was a bit unexpected but it turned out lovely because it actually didn't hurt as much as I thought it would. 

So my schedule starting Thursday: 

- Estradot patch every other day until CD1

- Orgalutran starting Friday morning for 3 days (Just 1 jab - easy peasy!)

Then the real deal: stimulation starting next CD2

- 400iu Puregon daily

- 75iu Repronex daily (Jab jab - at least I can alternate sides!)

CD6

- U/S and Bloodwork

- Start Orgalutran again on top of Puregon and Repronex (JAB JAB JAB - aaaaah! I'll be wishing for more jab-able surface area!)

As weird as it might sound, I was a kid at Christmas when I got home, dying to rip open my present. (A very expensive present, mind you!) 

Ahhh I couldn't wait to get my hands on these~ 

Now I'll have an excuse to be nasty! :p

So, I've added a reminder on my iPad everyday I have to do a patch or injection. Like I'll need it though! I'll probably be sitting next to my iPad with a needle in my other hand, waiting for the alarm to go off, then it's ready, set, JAB!!!!! Me talking about the burning sensation from the Repronex will be the highlight of the evening at the next gathering. Prepare to smile and nod while I bitch about everything~ You've been warned! :)

Day 9 Positive!

Woo Hoo! It's Day 9 and the results are positive! I'm not sure why I'm so excited because it's not even a pregnancy test! But at least something is going right and I got a positive result for SOMETHING!

I love smiley faces!!

Another step towards a positive end result!!

Now I won't need to do these tests anymore! I looked forward to them every day! (That's sad...)

Pixy Stix you pee on

SO... I went out and bought my Ovulation Kit today. TA DA~

My gosh they were expensive! $55.95 for 7. Of course, we went for the digital since I know if I get those ones with the lines, I'll be staring at the stick for half an hour deciding if a faint line means positive.

SO, it tells me to start testing on day... 7... I'm so tempted to start now even though I'm only on day 3! Hahaha! Although... I'm not sure why the doc wanted me to do these tests. How is when I ovulate this month important when I haven't even started my injections? Hmmm well, I'll leave things up to the pros. I trust you doc!

On another note, these stick packs sure look like Pixy Stix candy!! Mmmmmmm...

Even Beans thinks so~

Beans - "Mommy can I eat this?"

No, dear... stop staring at me...

My new beginning - The first day of the rest of my life

Yup. It's Day 1 in many ways. It's the first day that I'm finally off work and more importantly it's also the first day that dear Aunt Flo came to visit. What a nice coincidence!!! There's excitement, there's hopes, there's dreams, and there'll be the sound of pee hitting a stick and trickling down the toilet in the morning. Isn't that lovely!

After months of waiting and many surprises. We've finally made it to Day 1. The doctor appointments seemed endless and the waiting was worst. First it was waiting for the 6-month Lupron to wear off after surgery. Then, it was waiting for blood work, ultrasounds, semen analysis, and more blood work and more ultrasounds.

As I was have having severe pain again the past few months, I had another baseline ultrasound done and of course they found more cysts! (Two again. Somehow they like to come in groups of 2? The return of Bertha and Norm!?!?) Fortunately, they are small and will not interfere with my IVF! I'm gonna hang cloves of garlic up in my house! STAY AWAY!


So my RE finally give me the OK on the start of my cycle! Yay!

My Day 1 finally came along and I called in. The nurse then called me back within a few hours and told me to purchase a Ovulation Kit and use it until I see a positive result, then call again.

Hmmm These things don't come cheap!
Shopper's Drug Mart, Here I come!



My next appointment is on November 15 at 1:00, at which time the nurse will teach me how to injection crazy hormones in my body, which will probably make me a witch for the next 30 days.

I'm also finally done with work. Hats off to all those people dealing with this crap and working full time at the same time. I just couldn't do it. I was in pain, I'm also studying part-time, I had to get time off too frequently for appointments, and my stress level just went through the roof. So I made a decision and quit. It's nice to finally be able to focus on myself, to try be more healthy, stress-free, and focus on my IVF cycle and school for the time being. I'm sure school will keep me plenty busy as I have an exam this Saturday. Oh wait, why am I blogging here when I should be studying?

So... more to come... peeing on a stick, jabbing myself with needles, and me turning into a nasty old crab! Yay! Aren't you excited?